EFFECT OF Phyllanthus amarus AND N-HEXADECANOIC ACID ON BLOOD COAGULATION PARAMETERS OF LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION IN WISTAR RATS
- Project Research
- 1-5 Chapters
- Qualitative
- Library / Doctrinal
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Blood clotting is a complex sequence of processes involving multiple proteins (factors) that must operate in a specific order to create a clot. The procedure is rapid and effective, but it must be monitored because uncontrolled clotting can lead to thrombosis. A shift in the balance of blood coagulation and coagulation inhibition, favoring either pro- or anticoagulation, can result in life-threatening thromboembolism or bleeding. This study evaluated the effect of ethanol Phyllanthus amarus extract and n-hexadecanoic acid on blood coagulation parameters of lipopolysaccharide-induced inflammation in Wistar rats. Thirty rats were used for the study and were divided into six different groups with each group containing five rats. Oral administration of plant extract lasted for twenty-one days after which inflammation was induced in the rats with a single dose of lipopolysaccharide (1 mg/kg) intraperitoneally. Blood coagulation parameters like prothrombin time (PT), activated partial thromboplastin time (aPTT) and fibrinogen concentration were parameters considered in testing clotting time. The packed cell volume (PCV) of the experimental rats was also determined. The result of the study showed there was significantly shorter (p < 0.05) PT, and increased fibrinogen concentrations in the treatment groups compared with the negative and normal control groups. Fibrinogen concentration in the experimental animals showed a shortened clotting time that was more pronounced in the negative control group. There was no significant difference in the PCV of the experimental animals. The aPTT is shortened in the positive control when compared with the normal control (p=0.0226). This indicates the procoagulant activity of the Phyllanthus amarus extract and n-hexadecanoic acid.
Keywords: Blood coagulation, Fibrinogen concentration, Lipopolysaccharides, N-hexadecanoic acid, Phyllanthus amarus.
Related Project Materials
INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) DEPLOYMENT IN ARCHITECTURAL FIRMS IN NIGERIA
ABSTRACT
Architectural practice has been in existence in Nigeria for more than fifty years and the earliest introduction of computers by...
EXAMINATION OF E-MARKETING AND SMALL BUSINESS IN NIGERIA
EXCERPT FROM THE STUDY
Several scholars have cited potential benefits of Internet marketing. Some of the benefits mentio...
EFFECT OF IRRIGATION USING WATER FROM FISH PONDS ON PLANT GROWTH IN NORTHEASTERN NIGERIA
ABSTRACT
The irrational consumption of water is one of the greatest problem in the world today. Irrigation of agricultural crops with fis...
MARKET SEGMENTATION AS AN EFFICIENT TOOL OF ACHIEVING INCREASED MARKET SHARE
Abstract
This main aim of business is to seek, attract and retain customers who will use the company various products to...
THE ROLE OF AN AUDITOR IN SMALL BUSINESS ORGANIZATION
ABSTRACT
A significant contribution to the development and survival of business organization is the role that auditors p...
AN EXAMINATION OF SOCIETAL INFLUENCE ON YOUTH RITUALISM
ABSTRACT
This focus of this study is on the examination of societal influence on youth ritualism u...
THE EFFECTIVENESS OF VOCATIONAL EDUCATION IN REDUCING UNEMPLOYMENT RATES
ABSTRACT: This study examines the effectiveness of vocational education in reducing unemployment rates, focusing on the outcomes and impact of...
EVALUATION OF THE BINDING PROPERTIES OF ENZYME - HYDROLYZED CASSAVA STARCH IN CHLOROQUINE PHOSPHATE TABLET FORMULATIONS
ABSTRACT
Starch is a major carbohydrate, easily extractable from various sources like cassava, maize, potato etc which find wide applicat...
ASSESSMENT OF SCHOOL MAPPING ON ALLOCATION OF SCHOOL FACILITIES IN SECONDARY SCHOOLS IN NIGERIA
ABSTRACT
The study is titled “Assessment of school mapping on allocation of school facilities in secondary schools in Kaduna State,...
RELATIONSHIP BETWEEN SOCIAL MEDIA USE AND LEVEL OF DEPRESSION AMONG UNIVERSITY STUDENTS IN NAIROBI COUNTY, KENYA
ABSTRACT
Social media use has increased tremendously, with an estimated 3.5 billion users globally. A significant number of that populati...
